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ea0090p440 | Pituitary and Neuroendocrinology | ECE2023

DUONEN multicenter study - personalized PRRT treatment with 177Lu- or 177Lu/90Y-DOTA-TATE in patients with neuroendocrine tumors based on individual dosimetry

Opalinska Marta , Kamiński Grzegorz , Dedecjus Marek , Kowalska Aldona , Kolodziej Maciej , Saracyn Marek , Garnuszek Piotr , Lenda-Tracz Wioletta , Borkowska Anna , Gąsior-Perczak Danuta , Budzyńska Anna , Kubik Agata , Kacperski Krzysztof , Szubstarska Patrycja , Chalewska Wioletta , Długosińska Joanna , Januszkiewicz-Caulier Joanna , Hubalewska-Dydejczyk Alicja , Mikolajczak Renata

Introduction: The good expression of somatostatin receptors in neuroendocrine tumor tissue enables effective treatment with peptide receptor radionuclide therapy (PRRT). To date, there is no clear consensus on the optimal PRRT arrangement due to the possibility of the use of different radiopharmaceutical regimens. In theory, the simultaneous use of two radionuclides (90Y and 177Lu) with different energy and radiation ranges should be more effective than monotherapy. The main o...

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ea0099ep601 | Pituitary and Neuroendocrinology | ECE2024

Personalized dosimetry as a key for optimizing radioligand therapy (RLT) with 177Lu- or 177Lu/90Y-DOTA-TATE in patients with well-differentiated neuroendocrine tumors – an update on the initial results of the DUONEN multicenter study

Opalinska Marta , Kamiński Grzegorz , Dedecjus Marek , Kowalska Aldona , Kolodziej Maciej , Saracyn Marek , Garnuszek Piotr , Lenda-Tracz Wioletta , Gąsior-Perczak Danuta , Borkowska Anna , Januszkiewicz-Caulier Joanna , Długosińksa Joanna , Sowa Staszczak Anna , Budzyńska Anna , Kubik Agata , Kacperski Krzysztof , Chalewska Wioletta , Cegła Paulina , Hubalewska-Dydejczyk Alicja , Mikolajczak Renata

Aim/Introduction: Peptide Receptor Radionuclide Therapy (PRRT) is an effective treatment for disseminated neuroendocrine tumors (NETs) expressing somatostatin receptors. Despite many published studies, the consensus on the optimal PRRT treatment algorithm has not been reached yet. The main objective of the DUONEN multicenter, randomized, phase III study (EUDRACT No: 2020-006068-99) is the development of a dosimetry-based personalized PRRT algorithm. The second goal includes th...

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Endocrine Abstracts

DUONEN multicenter study - personalized PRRT treatment with 177Lu- or 177Lu/90Y-DOTA-TATE in patients with neuroendocrine tumors based on individual dosimetry

Personalized dosimetry as a key for optimizing radioligand therapy (RLT) with 177Lu- or 177Lu/90Y-DOTA-TATE in patients with well-differentiated neuroendocrine tumors – an update on the initial results of the DUONEN multicenter study

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